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Aug 20, 2018 · The X-ray co-crystal structure of MMP-13 in complex with 1 revealed that the inhibitor bound within the known S1' subsite. ... The p-methylphenyl ...
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Inhibitors for matrix metalloproteinases (MMPs) are under investigation for the treatment of cancer, arthritis, and cardiovascular disease.
We report crystal structures of catalytically inactive full-length human MMP-13(E223A) in complex with peptides of 14–26 aa derived from the cleaved prodomain ...
Sep 21, 2000 · The high-resolution NMR solution structure of the catalytic fragment of human collagenase-3 (MMP-13) was used as a starting point for ...
[PDF] Structure-Based Design and Synthesis of Potent and Selective ...
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Comparative structural analysis and design of Zn-chelating inhibitors. (A) X-ray crystallographic structure of MMP13·5 complex (PDB 4L19). Hydrogen bond ...
Feb 27, 2007 · Discovery and characterization of a novel inhibitor of matrix metalloprotease-13 that reduces cartilage damage in vivo without joint fibroplasia ...
Oct 1, 2018 · The X-ray co-crystal structure of MMP-13 in complex with 1 revealed that the inhibitor bound within the known S1′ subsite. ... The p-methylphenyl ...
Nov 7, 2014 · Indeed, a co-crystal structure of a highly specific MMP13 inhibitor with the catalytic domain of MMP13 revealed a non-zinc binding mode that ...
Matrix metalloproteinase-13 (MMP13) is a Zn2+. -depend- ent protease that catalyzes the cleavage of type II collagen, the main structural protein in articular ...
Jul 21, 2009 · The matrix metalloproteinase enzyme MMP-13 plays a key role in the degradation of type II collagen in cartilage and bone in osteoarthritis ...
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